Single-use Bioprocessing Bag Market Size, Share, Growth, and Industry Analysis, By Types (Single-use Bioreactor Bag, Single-use Mixing Bag, 2D/3D Storage Bag, Cell Culture Bag, Others), Applications (Biopharmaceutical, CDMO, Others) and Regional Forecast to 2033

Unique Information about the Single-use Bioprocessing Bag Market Size

The global single-use bioprocessing bag market was valued at USD 3,125 million in 2024 and is expected to reach USD 9,286.83 million in 2025. By 2033, the market is projected to grow to USD 34,43.75 million, registering a growth rate of 10.2% during the forecast period from 2025 to 2033.

The U.S. single-use bioprocessing bag market is a key player in the global industry, driven by robust pharmaceutical and biotech sectors, increasing demand for biologics, and advancements in biomanufacturing technologies, contributing to significant market growth.

The single-use bioprocessing bag market has experienced significant growth due to the increasing demand for biopharmaceuticals and the adoption of disposable technologies in drug manufacturing. These bags are essential in various bioprocessing applications, including cell culture, filtration, and storage, offering advantages such as reduced risk of cross-contamination and lower operational costs. The market is characterized by a diverse range of products, including single-use bioreactor bags, mixing bags, and storage bags, catering to the evolving needs of the biopharmaceutical industry.

Single-use Bioprocessing Bag Market Trends

The single-use bioprocessing bag market has witnessed notable trends in recent years, driven by advancements in biopharmaceutical manufacturing and the increasing demand for biologics. A significant trend is the growing adoption of single-use technologies across various stages of bioprocessing. These technologies offer benefits such as reduced risk of cross-contamination, lower operational costs, and enhanced flexibility in manufacturing processes. For instance, single-use bioreactor bags are increasingly utilized for cell culture applications, providing a cost-effective and efficient solution for biopharmaceutical production.

Another trend is the expansion of the market in emerging regions, particularly in Asia-Pacific. Countries like China and India are experiencing rapid growth in the biotechnology sector, leading to increased demand for single-use bioprocessing bags. This expansion is attributed to factors such as rising investments in biotechnology, a growing number of biopharmaceutical companies, and supportive government policies promoting the development of the life sciences industry.

The market is also witnessing a shift towards more sustainable and environmentally friendly single-use bioprocessing solutions. Manufacturers are developing bioprocessing bags made from biodegradable materials and implementing recycling programs to address environmental concerns associated with disposable products. This trend aligns with the broader industry movement towards sustainability and reducing the environmental impact of biopharmaceutical manufacturing.

Drivers of Market Growth

"Rising Demand for Pharmaceuticals"

The increasing demand for pharmaceuticals, driven by a growing global population and the prevalence of chronic diseases, is significantly impacting the bioprocessing industry. For example, according to the World Health Organization, over 40% of the global population suffers from some form of chronic disease, contributing to higher demands for pharmaceuticals. Bioprocessing technologies, particularly single-use bags, are increasingly favored due to their efficiency and flexibility in pharmaceutical production. The rise of biologic drugs, with a global market expected to reach $500 billion by 2027, is also a significant driver, fueling demand for single-use bioprocessing solutions in drug development and manufacturing.

Market Restraints

"Demand for Refurbished Equipment"

A significant restraint in the growth of the single-use bioprocessing bag market is the rising preference for refurbished equipment. Due to high initial investment costs associated with new single-use bioprocessing bags, many smaller biopharma companies and laboratories prefer refurbished or recycled equipment. This limits the demand for new bags, as refurbished bags can offer cost-saving solutions. According to a report by Grand View Research, the cost of new equipment in bioprocessing has been identified as a barrier, especially for smaller players who might prioritize reducing capital expenditures over adopting new technologies.

Market Opportunities

"Growth in Personalized Medicines"

Personalized medicine, which tailors medical treatment to the individual characteristics of each patient, presents a significant opportunity for the single-use bioprocessing bag market. The global personalized medicine market is expected to see substantial growth, driven by advancements in genomic research and biotechnology. For instance, the increase in targeted therapies and cell and gene therapies necessitates flexible and scalable manufacturing processes, where single-use bags can play a pivotal role. These bags offer advantages such as reduced risk of cross-contamination and faster setup times, aligning perfectly with the needs of personalized medicine production.

Market Challenges

"Rising Costs and Expenditures Related to Pharmaceutical Manufacturing Equipment"

A challenge facing the single-use bioprocessing bag market is the escalating costs associated with pharmaceutical manufacturing equipment. The development and integration of advanced bioprocessing technologies, including single-use systems, require significant capital investment. Furthermore, the operational costs involved in ensuring quality and compliance with regulatory standards can be burdensome for manufacturers. In particular, the increasing need for stringent validation and sterilization processes to meet good manufacturing practices (GMP) standards adds additional financial pressure. According to the Pharmaceutical Technology Journal, regulatory compliance can account for up to 30% of the total costs involved in biomanufacturing, further compounding the challenges in the sector.

Segmentation Analysis

The single-use bioprocessing bag market can be segmented based on type and application. Each segment offers distinct opportunities for growth and innovation in various biotechnological processes. The segmentation allows for more targeted solutions in pharmaceutical production, from upstream processes like cell culture to downstream processes such as mixing and storage. As demand for biopharmaceuticals continues to rise, the market is witnessing increased adoption of specific types of single-use bioprocessing bags, which are tailored for distinct applications. The application of single-use bags extends across the biopharmaceutical sector, contract development and manufacturing organizations (CDMOs), and other industrial sectors, each leveraging unique properties to enhance efficiency and cost-effectiveness in biomanufacturing.

By Type

• Single-use Bioreactor Bag : Single-use bioreactor bags are gaining popularity due to their flexibility, efficiency, and cost-effectiveness in cell culture processes. These bags eliminate the need for traditional stainless-steel reactors, reducing operational complexity and capital expenditure. Their ability to maintain sterility, combined with improved scalability for large-volume production, makes them increasingly favored by biopharmaceutical manufacturers. The market for single-use bioreactor bags is growing rapidly as more companies adopt disposable systems for cell-based therapies, bioprocessing, and vaccine production. This type of bag is particularly useful in large-scale production settings, reducing the need for cleaning and sterilization between batches.

• Single-use Mixing Bag :Single-use mixing bags are designed for efficient blending of materials, including buffers, media, and other ingredients. They are widely used in biopharmaceutical manufacturing for their ability to provide a sterile environment, which reduces the risk of contamination during production. The growth of biologic drug manufacturing and increased demand for faster production timelines are key drivers behind the market expansion for these bags. As they eliminate the need for manual mixing, single-use mixing bags also contribute to increased productivity. A study by BioProcess International found that single-use mixing bags can cut mixing times by up to 50%, leading to faster process cycles.

• 2D/3D Storage Bag : 2D and 3D storage bags are used primarily for the storage and transport of cell cultures and other sensitive biological materials. The key distinction between the two is that 3D storage bags offer additional depth and structural support, making them ideal for large-scale storage applications. The growing emphasis on biologic drug development and gene therapies, which require stringent storage conditions, is driving the demand for these types of bags. 3D bags, in particular, are increasingly used in cell therapy applications, where maintaining cell viability and ensuring sterility during storage are paramount. Their ability to store larger volumes and maintain a stable environment makes them crucial in the bioprocessing industry.

• Cell Culture Bag : Cell culture bags are specifically designed for culturing cells in a sterile and controlled environment. These bags are utilized in the upstream stages of bioprocessing, where cells are grown to produce biologic drugs, vaccines, and other pharmaceutical products. With the increasing adoption of cell and gene therapies, the demand for cell culture bags is surging. They are particularly advantageous in reducing contamination risks and simplifying scaling up processes. Market analysis from the Journal of Biotechnology indicates that cell culture bag usage has increased by over 20% in recent years due to advancements in cell-based therapies and regenerative medicine.

• Others : Other types of single-use bioprocessing bags include applications for mixing and transport, such as tangential flow filtration (TFF) bags and sample collection bags. These bags serve specialized roles in the purification and filtration processes involved in biomanufacturing. The diversity in single-use bag applications allows for customization, meeting the needs of various stages of the bioprocessing workflow, from production to post-production analysis. As biopharmaceutical manufacturing becomes more specialized, demand for these niche bag types is expected to increase, providing tailored solutions for unique production challenges.

By Application

• Biopharmaceutical : The biopharmaceutical segment holds the largest share in the single-use bioprocessing bag market. With the growing need for biologic drugs, vaccines, and gene therapies, the demand for efficient and flexible bioprocessing solutions is at an all-time high. The use of single-use bioreactor bags, cell culture bags, and mixing bags in this sector is critical for maintaining sterile conditions, reducing cross-contamination, and speeding up production timelines. The pharmaceutical industry’s transition toward biologics has driven biopharma companies to increasingly adopt single-use technologies. The global biologics market is projected to grow to approximately $500 billion by 2027, a trend that supports the continued adoption of single-use bioprocessing bags.

• CDMO : Contract Development and Manufacturing Organizations (CDMOs) are also significant users of single-use bioprocessing bags, as these companies handle production for various pharmaceutical and biotechnology firms. The rise of outsourcing in biomanufacturing and the increasing complexity of biologic drug production has led CDMOs to adopt more flexible, efficient, and cost-effective technologies like single-use bioprocessing bags. CDMOs can now scale production quickly without the need for costly investment in stainless-steel systems, allowing them to serve multiple clients with varying production needs. This market segment is seeing growth, particularly as more pharmaceutical companies seek third-party manufacturers for biologics.

• Others : The "Others" category encompasses various industrial sectors, including food and beverage, cosmetics, and environmental testing, where single-use bioprocessing bags are used for specific applications such as ingredient mixing, testing, and sample storage. In food and beverage processing, single-use bags are often employed in bioreactor systems used for fermentation processes. Additionally, in the cosmetic industry, these bags are used in the production of biocompatible ingredients and skincare products. The diversification of applications for single-use bioprocessing bags beyond pharmaceuticals and CDMOs presents an expanding market for these products, contributing to their growth in non-biotech sectors.

Regional Outlook

The global single-use bioprocessing bag market is experiencing varied growth across different regions, driven by factors such as advancements in biotechnology, healthcare infrastructure, and biopharmaceutical manufacturing. North America remains a leading region in the adoption of single-use bioprocessing technologies due to a robust pharmaceutical and biotechnology sector. Europe follows closely with a focus on regulatory standards and biomanufacturing excellence. Asia-Pacific is witnessing rapid adoption, driven by increasing demand for cost-effective biomanufacturing solutions and emerging markets in China and India. Meanwhile, the Middle East and Africa are seeing gradual market penetration, with an emphasis on expanding healthcare capabilities and improving biomanufacturing efficiency.

North America

North America is one of the dominant markets for single-use bioprocessing bags, largely driven by the United States, which holds a significant share in the global biopharmaceutical sector. The U.S. pharmaceutical industry continues to expand, with total revenue reaching approximately $500 billion in 2024, encouraging widespread adoption of single-use technologies. The region’s advanced healthcare infrastructure, stringent regulatory standards, and research and development capabilities contribute to its strong market position. The presence of major pharmaceutical companies such as Pfizer, Merck, and Johnson & Johnson further accelerates the use of single-use bioprocessing bags, particularly in biologic drug production and vaccine manufacturing.

Europe

Europe holds a significant share of the global single-use bioprocessing bag market, driven by countries such as Germany, the United Kingdom, and Switzerland, which are known for their strong biopharmaceutical industries. The European Union’s robust regulatory framework for pharmaceutical manufacturing has spurred growth in the adoption of single-use technologies. The region is home to a number of leading contract development and manufacturing organizations (CDMOs), such as Lonza and Wacker Chemie, which are increasingly adopting single-use bioprocessing bags for flexible and scalable production. Moreover, the European Medicines Agency (EMA) has played a key role in setting standards that encourage the adoption of such technologies in biologics manufacturing.

Asia-Pacific

Asia-Pacific is emerging as a high-growth region in the single-use bioprocessing bag market, with increasing demand from countries like China, Japan, and India. The region’s expanding biopharmaceutical industry, driven by large populations and rising healthcare needs, is contributing significantly to market growth. China, in particular, is becoming a hub for biologic drug production and is rapidly adopting single-use bioprocessing technologies to streamline production processes. The government’s focus on boosting its domestic biopharmaceutical capabilities is evident through initiatives to promote biotechnology development, making Asia-Pacific a key region for the expansion of the single-use bioprocessing bag market. India is also seeing a rise in biologics and contract manufacturing demand.

Middle East & Africa

The Middle East and Africa (MEA) region is gradually increasing its use of single-use bioprocessing bags, albeit at a slower pace compared to other regions. The growing focus on improving healthcare infrastructure, particularly in countries like Saudi Arabia, the UAE, and South Africa, is contributing to this trend. The region is investing in biopharmaceutical manufacturing capabilities, which is expected to drive the demand for single-use technologies. The Middle East is looking to establish itself as a hub for manufacturing and distribution of biologics, and as a result, there is growing interest in single-use solutions that offer flexibility and cost-effectiveness in the manufacturing process. While the market share in MEA is currently smaller, the region presents significant growth potential over the coming years.

List of Key Single-use Bioprocessing Bag Market Companies Profiled

• Sartorius
• Cytiva
• Entegris
• Merck Millipore
• Thermo Fisher
• Avantor
• Saint-Gobain
• Corning
• JYSS Bio-Engineering
• Lepure Biotech
• Shanghai Duoning Biotechnology

Companies with Highest Market Share

• Sartorius – Sartorius is a leading player in the single-use bioprocessing bag market, accounting for the largest market share due to its extensive portfolio of high-quality bioprocessing equipment and its strong presence in the global biopharmaceutical industry.
• Cytiva – Cytiva is another dominant player with a significant market share, recognized for its broad range of single-use technologies and solutions catering to the biopharmaceutical and biotech sectors.

Investment Analysis and Opportunities

The single-use bioprocessing bag market presents promising investment opportunities, driven by several factors including technological advancements, increasing demand for biologics, and the rise of personalized medicine. Investment in this market is expected to focus primarily on enhancing production capabilities, expanding research and development facilities, and forming strategic partnerships with pharmaceutical companies and contract manufacturers. For instance, leading companies in this space are heavily investing in advanced manufacturing techniques to produce more efficient and cost-effective single-use bags, allowing for better scalability in biopharmaceutical production.

As governments worldwide continue to emphasize healthcare and biotechnology as priority sectors, investments in infrastructure and technology are on the rise. Emerging markets, particularly in Asia-Pacific and Latin America, are attracting considerable foreign investments due to their growing pharmaceutical industries and the demand for cost-efficient biomanufacturing solutions. Additionally, investments in sustainability are growing, as manufacturers seek environmentally friendly alternatives for single-use products. Furthermore, there is a growing trend of mergers and acquisitions in the bioprocessing sector, as large players look to expand their technological capabilities and strengthen their product portfolios.

The increasing demand for biologics and biosimilars, particularly in regions like North America and Europe, has opened new opportunities for the single-use bioprocessing bag market. Furthermore, with personalized medicines gaining traction, there is an opportunity to develop specialized single-use products for small-batch production, enhancing the market potential for companies involved in this space.

New Products Development

New product development within the single-use bioprocessing bag market is focused on improving the functionality, efficiency, and environmental footprint of bioprocessing solutions. Companies are focusing on the development of multi-functional bags that can be used across different stages of bioprocessing, from cell culture to filtration, reducing the number of products required and enhancing cost-effectiveness. For example, recent product developments by companies like Sartorius and Thermo Fisher have focused on creating bioreactor bags with enhanced scalability and automation capabilities, which is especially critical as the production of biologics becomes more complex.

The trend toward developing products that address the specific needs of cell and gene therapy manufacturing is also evident. With the increase in demand for personalized treatments, new single-use products are being introduced that cater specifically to these complex and small-batch manufacturing requirements. These new products often feature advanced material formulations to reduce the risk of contamination and improve sterility. In addition, the push for sustainability has led companies to focus on developing biodegradable or recyclable single-use bags, providing a more environmentally friendly option for biopharma manufacturers.

A key area of innovation is the development of 3D bags for more efficient cell culture, with several companies introducing products that allow better gas exchange and temperature regulation. The introduction of integrated solutions that combine filtration, mixing, and storage in a single bag system is another growing trend, aimed at simplifying and optimizing the bioprocessing workflow.

Recent Developments by Manufacturers in the Single-use Bioprocessing Bag Market 

• Sartorius launched a new line of high-performance, large-volume single-use bioreactor bags designed to meet the growing demands of cell and gene therapy production in 2024.
• Cytiva introduced a series of next-generation single-use mixing bags in 2023, featuring advanced materials to improve mixing efficiency and reduce process time.
• Thermo Fisher developed an innovative single-use filtration system in 2024 that combines filtration and storage functions, reducing the number of steps in biomanufacturing.
• Avantor unveiled a new range of cell culture bags with improved oxygen permeability in 2023, aimed at enhancing cell growth for biologic drug production.
• Merck Millipore launched a highly customizable single-use bag platform in early 2024 that allows for the integration of various bioprocessing stages, streamlining production processes for large-scale manufacturing.

Report Coverage

This report provides a comprehensive analysis of the global single-use bioprocessing bag market, including market trends, drivers, challenges, opportunities, and key player profiles. It covers detailed insights into the market segmentation by type and application, offering a deep dive into the various product types, including single-use bioreactor bags, mixing bags, storage bags, and cell culture bags. The report also explores regional market dynamics, focusing on North America, Europe, Asia-Pacific, and the Middle East & Africa, identifying growth trends and key drivers for each region. Additionally, it covers investment opportunities and strategies employed by key market players, as well as new product developments and recent market innovations. This report is crucial for stakeholders seeking to understand the competitive landscape and make informed decisions in the growing single-use bioprocessing bag market.